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Immune Deficiency & Neuromuscular disorders (Immune globulin therapy)

What are primary immune deficiency disorders?
The term “primary immune deficiency disorder” means medical condition resulting from the inherited defects of the immune system, which is known to fight off bacteria and virus. Although there are different diseases/disorders to cause immune deficiency in different ways with different signs and symptoms, patients usually require immune globulin therapy to prevent getting sick from other diseases like infections.

List of primary immune deficiency disorders that may require immune globulin therapy:
Common variable immunodeficiency (CVID)
Hypogammaglobulinemia
Severe combined immunodeficiency (SCID)
Transient hypogammaglobulinemia of infancy
Wiskott-Aldrich syndrome (WAS)
X-linked agammaglobulinemia (XLA) (congenital agammaglobulinemia)

What are autoimmune neuromuscular disorders (myasthenia gravis)?
In this disorder, our body’s immune system attacks our own body to causing skeletal muscle weakness and fatigue. The body makes auto-antibodies targeting our own acetylcholine receptors and leading to dysfunction in muscle coordination. Although there are variety of options for treatments, immune globulin therapy can used at certain stages of the disorder to reverse an exacerbation.

What is immune globulin therapy?
Immune globulin (IG) is a mixture of antibodies that are produced by our immune system to fight off foreign substances like bacteria or virus that can make our body sick. These IGs are extracted from the blood of strictly screened volunteer donors, and made into medically useful treatments. Immune globulins can be given to those who lack these helpful antibodies usually either through the veins (intravenously, IV) or under the skin (subcutaneously, SQ) to maintain sufficient antibody level to protect the body from diseases like infections.

Medications:

  • Actimmune
  • Carimune
  • CytoGam
  • Flebogamma
  • Gammagard
  • GamaSTAN S/D
  • Gammaked
  • Gammaplex
  • Gamunex-C
  • Hizentra
  • Hyqvia
  • MICRhoGAM
  • Octagam
  • Privigen
  • RhoGAM
  • Rhophylac
  • WinRho

Additional links:
http://www.info4pi.org/
http://primaryimmune.org/
http://www.ipopi.org/
https://ghr.nlm.nih.gov/
http://www.cdc.gov/genomics/public/features/myasthenia_gravis.htm
http://www.aaaai.org/conditions-and-treatments/primary-immunodeficiency-disease
https://www.niaid.nih.gov/topics/immunedeficiency/Pages/Default.aspx

References:
www.uptodate.com.

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St. Jude Specialty Pharmacy
121 St. Nicholas Ave
Brooklyn , NY - 11237
Tel: 718-381-5116
Fax: 718-417-3621
E-mail: stjuderx@yahoo.com